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1994-10-25
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Document 2934
DOCN M94A2934
TI Pathology of the central nervous system of AIDS in Japan.
DT 9412
AU Funata N; Koike M; Tokyo Metropolitan Komagome Hospital, Japan.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):191 (abstract no. PB0191). Unique
Identifier : AIDSLINE ICA10/94369641
AB OBJECTIVE: Autopsy cases of AIDS were reviewed to find the
characteristic features in the pathology of the central nervous system
(CNS) in Japanese patients. In addition, we examined the presence of
Epstein-Barr virus (EBV) in CNS malignant lymphomas. METHODS: A
consecutive autopsy series of 35 patients was reviewed. EBER1 in situ
hybridization was applied to demonstrate EBV. RESULTS: HIV
encephalopathy and vacuolar myelopathy were observed in 29% and 11%,
respectively. Cytomegalovirus infection was the most frequent CNS
infection (29%), followed by progressive multifocal leukoencephalopathy
(11%) and toxoplasmosis (9%). Primary CNS lymphomas were present in 17%
while secondary involvement by systemic lymphoma was seen in 3%. EBV
could be detected in all cases of CNS lymphomas using in situ
hybridization (4/4). DISCUSSION AND CONCLUSIONS: The present study
confirms the frequent involvement of the CNS in Japanese patients with
AIDS. The incidence of HIV encephalopathy and vacuolar myelopathy in
Japan is not significantly different from that in other countries. It
seems that the frequency of CNS lymphomas is higher in Japan and EBV is
involved in pathogenesis of CNS lymphomas in AIDS.
DE Acquired Immunodeficiency Syndrome/*PATHOLOGY AIDS Dementia
Complex/*PATHOLOGY AIDS-Related Opportunistic Infections/PATHOLOGY
Brain/PATHOLOGY Brain Neoplasms/*PATHOLOGY *Herpesvirus 4,
Human/ULTRASTRUCTURE Human In Situ Hybridization Japan Lymphoma,
AIDS-Related/*PATHOLOGY Spinal Cord/PATHOLOGY Tumor Virus
Infections/*PATHOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).